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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADAM17
All Species:
14.24
Human Site:
S125
Identified Species:
26.11
UniProt:
P78536
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78536
NP_003174.3
824
93021
S125
H
V
V
G
E
P
D
S
R
V
L
A
H
I
R
Chimpanzee
Pan troglodytes
XP_001154844
807
90985
S125
H
V
V
G
E
P
D
S
R
V
L
A
H
I
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532870
787
87680
D121
N
Y
L
I
E
L
I
D
R
V
D
D
I
Y
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0F8
827
93055
S125
H
V
V
G
E
P
D
S
R
V
L
A
H
I
G
Rat
Rattus norvegicus
Q9Z1K9
827
92999
S125
H
V
V
G
E
P
D
S
R
V
L
A
H
I
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516484
430
47905
Chicken
Gallus gallus
NP_001008682
829
93588
N125
G
H
V
V
G
E
H
N
S
K
V
V
A
H
I
Frog
Xenopus laevis
Q8JIY1
749
84049
S114
F
G
E
Q
G
T
L
S
H
G
S
V
V
D
G
Zebra Danio
Brachydanio rerio
XP_689147
838
93831
N122
G
H
V
I
G
E
E
N
S
R
V
Q
A
H
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VAC5
732
83062
T102
V
D
A
D
G
N
E
T
V
V
H
M
D
H
D
Honey Bee
Apis mellifera
XP_623993
716
82155
I86
G
D
G
E
E
K
T
I
H
L
D
H
E
S
F
Nematode Worm
Caenorhab. elegans
NP_509318
686
77280
L56
D
Q
E
Y
V
V
D
L
E
P
N
H
S
T
F
Sea Urchin
Strong. purpuratus
XP_790625
763
85522
E117
S
V
V
K
M
H
L
E
G
D
D
I
T
A
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
N.A.
68.6
N.A.
91.9
92.1
N.A.
48
76.4
28.5
61.4
N.A.
37.3
37.2
26.3
33.2
Protein Similarity:
100
97.9
N.A.
72
N.A.
96.3
96.3
N.A.
50
87.2
44.7
74.8
N.A.
54.2
53
43.4
51.5
P-Site Identity:
100
100
N.A.
26.6
N.A.
93.3
93.3
N.A.
0
6.6
6.6
6.6
N.A.
6.6
6.6
6.6
20
P-Site Similarity:
100
100
N.A.
40
N.A.
93.3
93.3
N.A.
0
20
6.6
26.6
N.A.
20
13.3
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
0
0
31
16
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
16
0
8
0
0
39
8
0
8
24
8
8
8
8
% D
% Glu:
0
0
16
8
47
16
16
8
8
0
0
0
8
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% F
% Gly:
24
8
8
31
31
0
0
0
8
8
0
0
0
0
24
% G
% His:
31
16
0
0
0
8
8
0
16
0
8
16
31
24
0
% H
% Ile:
0
0
0
16
0
0
8
8
0
0
0
8
8
31
16
% I
% Lys:
0
0
0
8
0
8
0
0
0
8
0
0
0
0
0
% K
% Leu:
0
0
8
0
0
8
16
8
0
8
31
0
0
0
0
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
8
0
0
0
0
8
0
16
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
31
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
8
0
8
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
39
8
0
0
0
0
31
% R
% Ser:
8
0
0
0
0
0
0
39
16
0
8
0
8
8
0
% S
% Thr:
0
0
0
0
0
8
8
8
0
0
0
0
8
8
0
% T
% Val:
8
39
54
8
8
8
0
0
8
47
16
16
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
8
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _